-Always collect cans, Aether-giving discarded fruit, and other resources
-Stock up on Splines, Air Cans, Gas Cans, Watering Cans, etc. So you don't have to make them as you need them.
Have the forums open as you play!
-It can be VERY helpful for solving quests and discovering special areas.
Open/open special areas!
-Fill the Engines with Aether to open the fog gates and fight bosses, and also some missions require you to access them.
-Also, find the rainbow llama! Swim around in Evergreen Meadows...
When in doubt, SMASH IT!
-Always use your hammer, (if you have one) instead of using dinomite, which is expendable and very useful in battle. I mean, who can argue with 65 DAMAGE with a 100% hit chance!
Pick your weapons CAREFULLY!
-Once you get to around lvl. 20, you will have unlocked most weapons in the game and have choices. Coordinating your weapons can really improve your combat. (Ice on ice, tesla on tesla, oil and fire)
-Choose your weapon for the battle. Certain Automatons lose lose almost all their bite when the right weapons are use. (Combustionauts do virtually no damage when you are wet)
-Again, take advantage of Evergreen Meadows. Fight the framing Automatons (behind the bushes) and reap the rewards. They can reward up to 8 cans per battle! (And it takes about 4 good hits with a hammer to kill them.)
Restore your health at no cost!
-In small maps, such as Smuggler's Cove, if you are in a multiplayer battle, you can flee the battle with damage, re-spawn at the tele-cog, and return to the battle WITH FULL HEALTH!
I hope these tips help you and feel free to add your own advice.