Most of them know it since it's very popular, but I think Viswanathan Anand and Levon Aronian are the most prolific recent players to play it. Here's a game between Vishy and Hikaru from the 2013 Norwary Chess using the Murphy Defense line:
[Event "Norway Chess"]
[Site "Bryne NOR"]
[Date "2013.05.12"]
[EventDate "2013.05.08"]
[Round "4"]
[Result "0-1"]
[White "Viswanathan Anand"]
[Black "Hikaru Nakamura"]
[ECO "C78"]
[WhiteElo "2783"]
[BlackElo "2775"]
[PlyCount "78"]
1. e4 e5 2. Nf3 Nc6 3. Bb5 a6 4. Ba4 Nf6 5. O-O b5 6. Bb3 Bc5
7. c3 d6 8. d4 Bb6 9. Be3 O-O 10. Nbd2 Re8 11. Re1 Na5 12. Bc2
c5 13. dxc5 dxc5 14. Qe2 Ng4 15. Nf1 Be6 16. Ng5 Nxe3 17. Nxe6
fxe6 18. Nxe3 c4 19. Qh5 Qc7 20. Ng4 Rf8 21. Re2 Rad8 22. Rd1
Rxd1+ 23. Bxd1 Rd8 24. Bc2 b4 25. cxb4 Nc6 26. Ba4 Nxb4
27. Qxe5 Qe7 28. Qh5 Nxa2 29. g3 Nc1 30. Rc2 Nd3 31. e5 Rf8
32. Rxc4 Bxf2+ 33. Kg2 Bc5 34. Bc6 Rf5 35. Qh4 Ne1+ 36. Kh3
Qf7 37. Rxc5 Rh5 38. Bg2 Rxh4+ 39. gxh4 Qf5 0-1